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Dr. Chuck
Cochran, was recently asked why
Collastin and Collastin
Support (W/ Enzyrest) are so effective, "These two
formulas work synergistically to correct auto-immune challenges
or other inflammatory conditions that afflict tens of millions.
Collastin and Collastin Support contain three vital ingredient
groups that fight these ailments: Collastin™, Enzyrest™, and Glucosamine hydrochloride. In order to explain why these
ingredients are so important, you need to understand what’s
happening when there’s an auto-immune crisis in the body".
Our Recommendation is to
follow Dr. Cochran's advice and use Collastin and Collastin
Support....more
CETYL MYRISTOLEATE
(Collastin’s
Active Ingredient)
FEATURES
Cetyl Myristoleate is the
cetyl alcohol ester of
 myristoleic acid. Myristoleic acid is a
14 carbon chained monounsaturate
d omega-5 fatty acid. The
technical name for myristoleic acid is cis-9-tetradecenoic
acid. It is important to note that all Cetyl Myristoleate (CM)
products available today are presented in complexes of
acetylated fatty acids with varying percentages of CM. Clinical
observations have shown that the success of CM products can be
affected by the percentage of other fatty acids that also appear
in the raw materials. For instance, cetyl myristate may
actually enhance the effectiveness of the Cetyl Myristoleate
while cetyl oleate may compete for the same binding sites and
result in diminished effects.
Cetyl Myristoleate is a
nutritional breakthrough for improving joint health. It has
been clinically found to function comprehensively in:
·
Reducing pain
·
Reducing
inflammation
·
Lubricating joints
and surrounding tissues resulting in decreased joint crepitus
·
Modulating immune
function
BENEFITS
Cetyl
Myristoleate is often compared to polyunsaturated fatty acids (PUFAs)
and fish oils, high in n-3 fatty acids, in its ability to
regulate inflammation. However, the similarity stops there. CM
is much more comprehensive in that down regulates the
inflammatory processes much more quickly, reducing pain, and
restoring mobility and joint function all within relatively
short periods of time. No doubt the most intriguing findings
are the long lasting results and symptoms continue to
improve after the treatment has been discontinued.
Some individuals have experienced complete remission of symptoms
and restoration of joint mobility for several years after only
several months of CM treatment.
SCIENCE
Results
of Harry Diehl’s research (1962 – 1964) and the discovery of CM:
·
Mice have
a natural immunity to adjuvant-induced arthritis
·
The
molecule that provides this immunity is Cetyl Myristoleate
·
CM
circulates in the blood stream of mice at approximately 350
mg/kg bodyweight
·
With
proper doses of CM extracted from mice (450-500 mg/kg
bodyweight), he could provide rats with 100% immunity to
adjuvant-induced arthritis
·
After
injecting the CM into the rats, the highest concentrations were
found in the liver
·
Diehl
developed a method of synthesizing CM by combining cetyl alcohol
with myristoleic acid, and found that the synthesized form was
just as effective in providing rats immunity to arthritis as the
naturally occurring form.
Diehl HW,
May EL. Cetyl Myristoleate Isolated From Swiss Albino Mice: An
Apparent Protective Agent Against Adjuvant Arthritis in Rats.
J Pharma Sci 1994, Mar;83:296-299.
Results
of Clincyte / Imagenetix study:
Sixty-four patients with
chronic osteoarthritis of the knee participated in a
double-blind, placebo-controlled trial. They were evaluated at
baseline, day 30, and day 68 by physician assessment, knee
ranges of motion with goniometry, and the Lequesne
Algofunctional Index (LAI).
-
After
68 days patients treated with cetylated fatty acids (CFA)
exhibited significant (p<0.001) increase in knee flexion
(10.1º) compared to the placebo group (1.1º)
-
Patient responses to the LAI indicated a significant
(p<0.001) shift towards functional improvement for the
treated group (-5.4 points) compared to a modest improvement
in the placebo group (-2.1 points)
-
CFA
may be an alternative to the use of Nonsteroidal
anti-inflammatory drugs for the treatment of OA
Hesslink
R, et al, Cetylated Fatty Acids Improve Knee Function in
Patients with Osteoarthritis, J Rheumatology, 2002;
29:1708-12.
Results
of American Institute for Biosocial and Medical Research (AIBMR)
study:
Thirteen pre-menopausal women diagnosed with rheumatoid
arthritis participated in a 6-week open trial. Treatment
consisted of a 4-week period in which subjects consumed 2200 mgs
of powdered CM Complex (11-15% Cetyl Myristoleate) followed by a
2-week washout period. Evaluations were performed at day 1,
week 4, and week 6. Treatment effectiveness was assessed with
the Arthritis Impact Measurement Scale 2 (AIMS2), pain visual
analogue scale, handgrip strength, and erythrocyte sedimentation
rate.
-
Left
grip strength significantly improved by week-4, and remained
improved at week-6
-
Right
grip strength significantly improved by week-4, and
continued to improve during the next 2 weeks. t score
values climbed from 2.73 to 4.28, and p values improved from
<0.01 to <0.001
-
Pain
Visual Analogue Scale scores significantly improved by
week-4, and continued to improve during the subsequent 2
weeks. t scores went from 2.74 to 4.53, and p values
improved from <0.01 to <0.0005
-
Arthritis pain did not significantly improve by week-4,
however did improve by week-6 (p<0.002)
-
The
ability of subjects to complete household tasks improved
significantly by week-4 (p<0.02), however this improvement
was not maintained at week-6
-
Subject mood significantly improved by week-4, and remained
improved at week-6
-
Both
arm function and hand & finger function were not
significantly improved by week-4, but significantly improved
by week-6 (p<0.03 and P<0.003 respectively)
Barrager
E and Schiller R, An Open Trial Investigating the Efficacy of
Cetyl-Myristoleate Complex (CMC) in the Reduction of Symptoms
Associated with Rheumatoid Arthritis, GENESIS Center for
Integrative Medicine, Graham, WA 98338.
Results
of Siemandi study:
H.
Siemandi, MD, PhD performed a multi-clinic, randomized,
double-blind, placebo-controlled study on 382 patients diagnosed
with rheumatoid arthritis, osteoarthritis, and psoriatic
arthritis. Treatment consisted of a one-month protocol in which
the group was divided into three groups. Group A received 90
grams of a 12% Cetyl Myristoleate liquid drink and group B
received this same drink combined with sea cucumber extract, and hydrolyzed cartilage.
Group C received a flavored drink with no active material
(placebo). Outcome measures included a variety of patient
reported, physician reported, laboratory, and radiographic
assessments. Results expressed as percentage of improvement
-
Overall treatment response – group A (63.3%), group B
(87.3%), and group C (14.5%)
-
Physician assessment – group A (58.1%), group B (84.2%), and
group C (13.9%)
-
Patient assessment – group A (59.2%), group B (88.2%), and
group C (16.1%)
-
Joint
swelling – group A (47.5), group B (77.2%), and group C
(21.1%)
Siemandi,
H, The Effect of Cis-9-Cetyl Myristoleate and Adjunctive Therapy
on Arthritis and Auto-Immune Disease, Townsend Letter for
Doctors & Patients, Aug/Sep 1997, 58-63.
PHYSIOLOGY
The exact
mechanism of action of CM is unknown. However, recent research
has revealed some very strong evidence.
Iguchi K,
et al. Myristoleic Acid, A Cytotoxic Component in the Extract
from Serenoa Repens, Induces Apoptosis and Necrosis in Human
Prostatic LnCaP Cells. Prostate 2001; 47:59-65.
-
Cellular apoptosis and/or necrosis (reference above)
-
Cytokine and immune regulation. Cytokine activity is linked
to a process, known as myristoylation, in which myristic
acid is bound to glycine in specific membrane proteins and
is responsible for their activation. There is evidence that
human myristoylation may occur with other 14-carbon fatty
acids, including myristoleic acid. Cellular behaviors that
can be affected include various secretions, gene
transcription, chemotaxis, and proliferation and
differentiation of hematopoietic stem cells, including
T-cells. These behaviors directly affect immune function
and inflammatory activities and pain responses
Raju R,
et al. Mammalian myristoyl Co:A Protein N-myristoyltransferase.
MolCell Biochem 1995; 149/150:191-202.
CLINICAL
INDICATIONS
COMPARISON
WITH OTHER NATURAL JOINT HEALTH NUTRIENTS
After reading the physiology section, you will realize that CM
works quite differently from most joint health nutrients in the
marketplace today. The big sellers, methyl sulfonylmethane, and chondroitin sulfate, are known as
chondro-regenerative nutrients and provide the necessary
building blocks for cartilage, ligament, and tendon tissue
regeneration. Clinical studies, including Dr. Siemandi’s study,
have shown that combining the joint-rebuilding nutrients with CM
can enhance treatment results. Creating a truly efficacious
joint health product should not be an either/or proposition. CM
is now provided in powdered form for formulation as a liniment
for topical applications and soft gel formulation and
encapsulation.
This information gives you some insight into how and why
Collastin and Collastin Support can give you the relief you're
seeking from the severe pain of arthritis and the pain
associated with it. Order your future without pain today!
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