Arthritis

Dr. Chuck Cochran, was recently asked why Collastin and Collastin Support (W/ Enzyrest) are so effective, "These two formulas work synergistically to correct auto-immune challenges or other inflammatory conditions that afflict tens of millions. Collastin and Collastin Support contain three vital ingredient groups that fight these ailments: Collastin™, Enzyrest™, and Glucosamine hydrochloride. In order to explain why these ingredients are so important, you need to understand what’s happening when there’s an auto-immune crisis in the body".

Our Recommendation is to follow Dr. Cochran's advice and use Collastin and Collastin Support....more

CETYL MYRISTOLEATE

(Collastin’s Active Ingredient)

FEATURES

     Cetyl Myristoleate is the cetyl alcohol ester of myristoleic acid.  Myristoleic acid is a 14 carbon chained monounsaturate

d omega-5 fatty acid.  The technical name for myristoleic acid is cis-9-tetradecenoic acid.  It is important to note that all Cetyl Myristoleate (CM) products available today are presented in complexes of acetylated fatty acids with varying percentages of CM.  Clinical observations have shown that the success of CM products can be affected by the percentage of other fatty acids that also appear in the raw materials.  For instance, cetyl myristate may actually enhance the effectiveness of the Cetyl Myristoleate while cetyl oleate may compete for the same binding sites and result in diminished effects. 

     Cetyl Myristoleate is a nutritional breakthrough for improving joint health.  It has been clinically found to function comprehensively in:

·         Reducing pain

·         Reducing inflammation

·         Lubricating joints and surrounding tissues resulting in decreased joint           crepitus 

·         Modulating immune function 

BENEFITS

    Cetyl Myristoleate is often compared to polyunsaturated fatty acids (PUFAs) and fish oils, high in n-3 fatty acids, in its ability to regulate inflammation.  However, the similarity stops there.  CM is much more comprehensive in that down regulates the inflammatory processes much more quickly, reducing pain, and restoring mobility and joint function all within relatively short periods of time.  No doubt the most intriguing findings are the long lasting results and symptoms continue to improve after the treatment has been discontinued.  Some individuals have experienced complete remission of symptoms and restoration of joint mobility for several years after only several months of CM treatment.

SCIENCE

Results of Harry Diehl’s research (1962 – 1964) and the discovery of CM:

·         Mice have a natural immunity to adjuvant-induced arthritis

·         The molecule that provides this immunity is Cetyl Myristoleate

·         CM circulates in the blood stream of mice at approximately 350 mg/kg bodyweight

·         With proper doses of CM extracted from mice (450-500 mg/kg bodyweight), he could provide rats with 100% immunity to adjuvant-induced arthritis

·         After injecting the CM into the rats, the highest concentrations were found in the liver

·         Diehl developed a method of synthesizing CM by combining cetyl alcohol with myristoleic acid, and found that the synthesized form was just as effective in providing rats immunity to arthritis as the naturally occurring form.

Diehl HW, May EL. Cetyl Myristoleate Isolated From Swiss Albino Mice: An Apparent Protective Agent Against Adjuvant Arthritis in Rats.  J Pharma Sci 1994, Mar;83:296-299.

 Results of Clincyte / Imagenetix study:

     Sixty-four patients with chronic osteoarthritis of the knee participated in a double-blind, placebo-controlled trial.  They were evaluated at baseline, day 30, and day 68 by physician assessment, knee ranges of motion with goniometry, and the Lequesne Algofunctional Index (LAI).

• After 68 days patients treated with cetylated fatty acids (CFA) exhibited significant (p<0.001) increase in knee flexion (10.1º) compared to the placebo group (1.1º)
• Patient responses to the LAI indicated a significant (p<0.001) shift towards functional improvement for the treated group (-5.4 points) compared to a modest improvement in the placebo group (-2.1 points)
• CFA may be an alternative to the use of Nonsteroidal anti-inflammatory drugs for the treatment of OA

Hesslink R, et al, Cetylated Fatty Acids Improve Knee Function in Patients with Osteoarthritis, J Rheumatology, 2002; 29:1708-12.

Results of American Institute for Biosocial and Medical Research (AIBMR) study:

     Thirteen pre-menopausal women diagnosed with rheumatoid arthritis participated in a 6-week open trial.  Treatment consisted of a 4-week period in which subjects consumed 2200 mgs of powdered CM Complex (11-15% Cetyl Myristoleate) followed by a 2-week washout period.  Evaluations were performed at day 1, week 4, and week 6.  Treatment effectiveness was assessed with the Arthritis Impact Measurement Scale 2 (AIMS2), pain visual analogue scale, handgrip strength, and erythrocyte sedimentation rate.

• Left grip strength significantly improved by week-4, and remained improved at week-6
• Right grip strength significantly improved by week-4, and continued to improve during the next 2 weeks.  t score values climbed from 2.73 to 4.28, and p values improved from <0.01 to <0.001
• Pain Visual Analogue Scale scores significantly improved by week-4, and continued to improve during the subsequent 2 weeks.  t scores went from 2.74 to 4.53, and p values improved from <0.01 to <0.0005
• Arthritis pain did not significantly improve by week-4, however did improve by week-6 (p<0.002)
• The ability of subjects to complete household tasks improved significantly by week-4 (p<0.02), however this improvement was not maintained at week-6
• Subject mood significantly improved by week-4, and remained improved at week-6
• Both arm function and hand & finger function were not significantly improved by week-4, but significantly improved by week-6 (p<0.03 and P<0.003 respectively)

Barrager E and Schiller R, An Open Trial Investigating the Efficacy of Cetyl-Myristoleate Complex (CMC) in the Reduction of Symptoms Associated with Rheumatoid Arthritis, GENESIS Center for Integrative Medicine, Graham, WA 98338.

Results of Siemandi study:

     H. Siemandi, MD, PhD performed a multi-clinic, randomized, double-blind, placebo-controlled study on 382 patients diagnosed with rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.  Treatment consisted of a one-month protocol in which the group was divided into three groups.  Group A received 90 grams of a 12% Cetyl Myristoleate liquid drink and group B received this same drink combined with sea cucumber extract, and hydrolyzed cartilage.  Group C received a flavored drink with no active material (placebo).  Outcome measures included a variety of patient reported, physician reported, laboratory, and radiographic assessments.  Results expressed as percentage of improvement

• Overall treatment response – group A (63.3%), group B (87.3%), and group C (14.5%)
• Physician assessment – group A (58.1%), group B (84.2%), and group C (13.9%)
• Patient assessment – group A (59.2%), group B (88.2%), and group C (16.1%)
• Joint swelling – group A (47.5), group B (77.2%), and group C (21.1%)

Siemandi, H, The Effect of Cis-9-Cetyl Myristoleate and Adjunctive Therapy on Arthritis and Auto-Immune Disease, Townsend Letter for Doctors & Patients, Aug/Sep 1997, 58-63.

PHYSIOLOGY

     The exact mechanism of action of CM is unknown.  However, recent research has revealed some very strong evidence.

• Inhibition of 5-lipoxygenase (a potent mediator of inflammation)

Iguchi K, et al. Myristoleic Acid, A Cytotoxic Component in the Extract from Serenoa Repens, Induces Apoptosis and Necrosis in Human Prostatic LnCaP Cells. Prostate 2001; 47:59-65.

• Cellular apoptosis and/or necrosis (reference above)
• Cytokine and immune regulation.  Cytokine activity is linked to a process, known as myristoylation, in which myristic acid is bound to glycine in specific membrane proteins and is responsible for their activation.  There is evidence that human myristoylation may occur with other 14-carbon fatty acids, including myristoleic acid.  Cellular behaviors that can be affected include various secretions, gene transcription, chemotaxis, and proliferation and differentiation of hematopoietic stem cells, including T-cells.  These behaviors directly affect immune function and inflammatory activities and pain responses

Raju R, et al. Mammalian myristoyl Co:A Protein N-myristoyltransferase. MolCell Biochem 1995; 149/150:191-202.

CLINICAL INDICATIONS

• Osteoarthritis
• Rheumatoid arthritis
• Psoriatic arthritis
• Sjögren’s Syndrome
• Reiter’s Syndrome
• Fibromyalgia
• Prostatitis (non-bacterial)
• Polymyalgia rheumatica
• Ankylosing spondylitis

COMPARISON WITH OTHER NATURAL JOINT HEALTH NUTRIENTS

     After reading the physiology section, you will realize that CM works quite differently from most joint health nutrients in the marketplace today.  The big sellers, methyl sulfonylmethane, and chondroitin sulfate, are known as chondro-regenerative nutrients and provide the necessary building blocks for cartilage, ligament, and tendon tissue regeneration.  Clinical studies, including Dr. Siemandi’s study, have shown that combining the joint-rebuilding nutrients with CM can enhance treatment results.  Creating a truly efficacious joint health product should not be an either/or proposition.  CM is now provided in powdered form for formulation as a liniment for topical applications and soft gel formulation and encapsulation.      

This information gives you some insight into how and why Collastin and Collastin Support can give you the relief you're seeking from the severe pain of arthritis and the pain associated with it.  Order your future without pain today!

Testimonials

Full Recovery from Accident

"While skiing in 1988 I fell and damaged my wrist badly. As a result the cartilage wore out. It was difficult to give adjustments to my patients. I took everything with minimal results. I used to bench press 235 lbs., but after the accident I couldn't lift at all. The doctor wanted to operate. After just one week on these nutrients I had almost no pain. After 6 weeks, I have full range of motion and I can no bench press 185 lbs."
Dr. Jolyn, TX

KNEE PAIN GOES AWAY

In 1975, while I was playing golf, I jumped across a narrow ditch. I landed on a rock, twisted my knee and tore the cartridge so badly that I had to have surgery to repair it. I underwent a normal recovery but I have had some weakness in that knee ever since. Then, as I grew older, my knee began to ache and eventually the pain became excruciating. Being a pharmacist for over 30 years, I started trying every prescription drug that I could come up with to relieve the pain, swelling and inflammation. At best, relief was only temporary. I started trying nutritional supplements and none of them worked either until I took a 'Starter Pack' of Collastin, Enzyrest and Glucosamine Hydrochloride. All my symptoms, including the pain, are gone. What a difference it has made to my quality of life.
Travis, Mississippi

Conquering Asthma

For anyone who has never had an asthma attack, it's like your lungs are suddenly made of leather and you're fighting to inflate them. Even when you do, it still seems like you're just getting a trickle of air. You are literally fighting for each and every breath. My days at this point revolved around what time it was and when I could use my inhaler next - I was using three puffs of Albuterol five times a day, and the same of Vanceril. I began using these nutrients and didn't really notice anything significant for about 2 weeks, at which point I noticed I was going longer and longer between "needing" my inhaler. In the past, any medication that I had taken rarely ever helped me for more than a month. Now I have just finished my third month with continued success. I had almost forgotten how wonderful it is to sleep the whole night, much less not wake up in a panic, but actually able to breathe.
Mary, Texas

Fibromyalgia Pain Nearly Gone

I am 88 years old. I have suffered with Fibromyalgia for 11 years. After one week on the product I am sleeping all night and my pain is nearly gone. I have tried everything and nothing has worked for me until now.
Marie, Indiana

Spinal Arthritis

I have been using these amazing nutrients for one month. The results of the first week were unbelievable to me. I noticed changes in my mobility right away. I have been taking common Glucosamine and Chondroitin for the last six months with very little success. I have been struggling with lower back pain and spinal arthritis. My doctor found an arthritic condition in my chest two years ago. I can now get out of bed easy, tie my shoes, stand up straight, walk up and down stairs and enjoy it. I almost stopped playing golf because of a very restricted swing. My body and shoulder turn has returned and I am excited. I shot 71, on under par, the other day. Each day I find something new I can do better with more mobility and confidence.
Allen, Tennessee

AVOID Knee Replacement

"I've had seven surgeries on my knee as a result of a compound fracture of my femur when I was eighteen. I was in traction three months, all cartilage was removed and my kneecap was shaved. I subsequently tore my anterior crucia ligament. It was reattached with staples to the bone. Doctors wanted to do a knee replacement. I started taking the product and in not that many days the pain was gone and now no more stiffness. I can now bicycle and play racquetball!"
Ron, North Carolina


Multiple Sclerosis
I began to feel really good for the first time in years. I suffered for 15 years with severe back pain, tingling and numbness in my arms, legs, hands and face. I was told I had the back of a 76 year old woman and x-rays seemed to confirm the diagnosis. By June 1995, I had to lift my legs to cross them and I was unable to walk across a room without support. I was so fatigued when I came home nightly that I went directly to bed. It was extremely difficult as I had always been a super achiever. I was diagnosed with Multiple Sclerosis, September 1, 1995. My mother had Multiple Sclerosis but we, as her children, were told it was not hereditary. We were not told we had a genetic predisposition to the disease, so I never associated my symptoms with MS. After seeing my mother suffer for years on medication without relief, I refused to take the drugs (over $1000 per month) offered by my neurologist. Instead, I searched and tried many products promising improved health with on and off success. Then I found this product. It took me about three weeks to see positive results since I was extremely toxic, but within a short period of time I eliminated all the high-cost, ineffective supplements my naturopath had me on. Within two months I regained my high level of energy, no longer requiring a nap in the afternoon. I had no pain, tingling, numbness or aching. I also didn't have severe cramping during my menstrual cycle. My weight stabilized, my hands and feet were no longer cold and my hair was no longer falling out. Needless to say, my mood improved as I began to feel really good for the first time in years. I have had no MS symptom ology for several years. People have suggested that I may just be in remission. I know better because I had suffered continual pain and tingling for 15 years without an ounce of relief. It was not until I found this truly remarkable product . . . that I continually felt good. I am not on any medication and I maintain a normal, busy life. When I went for my last eye exam my doctor remarked that he was "amazed" at the improvement in my sight. He could correct me to 20/20 which was impossible before.
Joanne, Montana